St. Andrew was the brother of St. Peter and the first disciple called by Christ. St. Andrew went to Greece to preach the gospel, and tradition has it that he was crucified on a cross in the form of an 'X'.
The relic of St. Andrew's head was donated to Pius II (1460). Paul VI (1966) presented the relic as a gift to the Church of St. Andrew in Patras as a sign of friendship with the Greek Orthodox Church.